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Real-world mechanism validation examples Glaucoma neuroprotection case: 65-year-old with moderate glaucoma, pressure well-controlled at 14mmHg on drops but showing 2-3% yearly visual field loss
Hyperglycemia exacerbates mitochondrial electron transport chain (ETC) dysfunction and increases ROS production through advanced glycation end products and inflammatory pathways (Zhang et al., 2023
critical safety baseline Inflammatory markers: hsCRP, optional adiponectin, leptin TSH and free T4: Rules out thyroid dysfunction
