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Glutathione mutants

As the activation of both JNK and caspase-3 contributed to TNF-induced cell death with NF-B inhibition, we examined the effects of HFD consumption on the hepatic activation status of JNK and caspase-3 cleavage

doi:10.1016/j.cellimm.2005.10.002 Arshad SH, Karmaus W, Raza A, et al

Although the cargos of the best-understood systems are folded proteins or protein fibers, the transient interactions with the channel should theoretically enable secretins to translocate highly diverse molecules, including non-proteinaceous ones

We found that blocking the translation of NRF2 prevented GSH accumulation ( Figure 7F ) as well as negated the immunosuppressive action of melatonin treatment ( Figures 7H, I )