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The first is extracellular matrix biology, where fibroblast culture and rat wound-chamber studies from the Maquart and Simeon groups (1988-2000) reported stimulation of collagen synthesis, sulfated glycosaminoglycan synthesis and small proteoglycan expression, alongside upregulation of matrix metalloproteinase-2 and its tissue inhibitors, a simultaneous increase in both matrix deposition and matrix turnover
Research Status Research on BPC-157 is currently at an advanced preclinical stage, with a scientific literature comprising more than 100 peer-reviewed publications
Related studies mainly focus on in vivo intervention efficacy validation, exploration of combined intervention strategies, and optimization of pharmaceutical dosage forms, providing important experimental evidence for clinical intervention of obesity
Both contribute to immune balance
Neither type of evidence should be treated as interchangeable with human clinical evidence
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