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2015), and CAT protein levels were unchanged by a high-fat, high-fructose diet (An et al

In AD, cerebrovascular dysfunction occurs earlier among E4 carriers (Veitch et al., 2019), which could lead to impairments in nutrient sensing and metabolite exchange between the brain and periphery, thereby negatively impacting brain bioenergetics by rendering brain areas of high energetic needs (e.g., the hippocampus) vulnerable to pathologies such as amyloid (Veitch et al., 2019

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Tirzepatide, also known by its brand names Mounjaro and Zepbound, is an innovative medication designed to support weight loss by mimicking hormones that control appetite and blood sugar levels