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In a large RCT involving obese and prediabetic individuals, tirzepatide significantly delayed the onset of T2DM compared with placebo across multiple doses, with sustained benefits observed during long-term follow-up
GLP-1 medications are not indicated and would be harmful
Consistency ensures long-term benefits
Chronically sun-damaged melanomas express low levels of nuclear glutathione-S-transferase-pi: an epidemiological and clinicopathological study in Italy
Second, the follow-up durations in several trials were insufficient to assess long-term carcinogenesis
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