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NF-B increases the expression of inducible nitric oxide synthase (iNOS), proinflammatory cytokines (TNF- and IL-6), and oxidative stress indicators (Al-Brakati et al
In reproductive tissues, this results in faulty cell signaling, damaged gamete DNA, and disrupted tissue function, all of which are important for fertility
For instance, central administration of GLP-1R agonists increases the ability of insulin to suppress endogenous glucose production (Knauf et al., 2005
Some research has explored berberine's relationship with incretin hormones
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