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DPP-4 inhibitors prevent degradation of GLP-1 thereby increasing its systemic concentration

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According to NICE guidance (NG28), GLP-1 receptor agonists are recommended as treatment options for type 2 diabetes in specific circumstances

This is one reason head-to-head binding assays dont always match head-to-head secretion experiments and why researchers occasionally get surprised when GHRP-6 outperforms GHRP-2 in certain model contexts despite lower receptor binding affinity on paper

Vilsbll T, Krarup T, Madsbad S, et al