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Treatment of rats with roridin E caused minimal toxicity on the hepatic and renal tissue, however, co administration of linoleic acid with roridin E resulted in increase toxicity due to increased incorporation to the cell membrane or inhibit its biotransformation [159]
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Emerging evidence has demonstrated that abnormal RCD of tubular epithelial cells aggravates the development of DKD
Licensed UK alternatives for weight management include Wegovy (semaglutide 2.4 mg) under NICE TA875, and Mounjaro (tirzepatide) for eligible patients with type 2 diabetes
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