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Key distinctions from growth hormone include [5] : Peptide lacks growth hormone receptor binding domains (specifically binding site 2) Binding site 2 is required for receptor dimerization and activation Competitive binding assays showed AOD9604 cannot compete with hGH for receptor binding Does not function as a growth hormone receptor antagonist Glucose Metabolism Preservation Unlike full hGH, which can induce insulin resistance and hyperglycemia, AOD9604 demonstrates no adverse effects on carbohydrate metabolism

doi: 10.1128/MCB.24.3.1106-1121.2004 223 WojciechowskiMCMahmutovicLShuDYLovicuFJ

) 5769 (Blackwell Publishing, 2003)

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