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Rapid dose escalation, skipping meals entirely, or severe dehydration amplifies the likelihood of chest wall discomfort from vomiting-related muscle strain
It may also reduce the risk of worsening kidney disease, kidney failure, and cardiovascular death in adults who have type 2 diabetes and chronic kidney disease
Those cardiovascular events usually occur in older adults
Januvia requires dose adjustment when eGFR falls below 45 mL/min/1.73m, with a reduced dose of 50mg daily for moderate impairment (eGFR 30-45) and 25mg daily for severe impairment (eGFR below 30)
The company purchased more than 457,000 mealsat a total price of more than $9 millionto educate prescribers about Wegovy and other similar drugs it sells, known as GLP-1 agonists, according to a July 5 STAT report
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