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FIGURE 8 Nine different substances were declared as PCT medicines in the samples and, in order of occurrence frequency, they were hCG (n = 16), clomiphene (n = 14), tamoxifen (n = 7), exemestane (n = 7), anastrozole (n = 7), cabergoline (n = 6), mesterolone (n = 4), and letrozole (n = 2)

On the other hand, AR inhibitors inhibit high glucose-induced ROS production and apoptosis in HUVECs, restore Sirtuin 1 (SIRT1) expression and phosphorylation of AMPK1, and reduce mTOR phosphorylation, preventing hyperglycaemia-induced endothelial cell death and dysfunction [50]