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Introduction Plants respond to environmental stresses by regulating metabolic pathways that function to counteract resulting cellular damage

By competitively binding to p53, FOXO4-DRI displaces endogenous FOXO4, causing p53 nuclear exclusion and translocation to mitochondria where it triggers the intrinsic apoptotic pathway through caspase-3/7 activation

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Scientific Classification A small-molecule quinolinium derivative and selective nicotinamide N-methyltransferase (NNMT) inhibitor

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