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doi:10.1111/j.1467-2494.2005.00235.x 32
These peptides activate MRGPRX2, a mast-cell receptor that fires on positively charged, aromatic molecules and releases histamine into the tissue. Sodium and chloride ions screen the peptides positive charge, so the receptor sees less of it and the welt shrinks
doi:10.1152/ajpendo.1997.273.1.E130 Chernausek SD, Backeljauw PF, Frane J, Kuntze J, Underwood LE
A recent human pilot study (Lee et al., 2024) examined intravesical BPC 157 injection at 10 mg in patients with interstitial cystitis, with observation of symptom improvements in 12 subjects
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