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Exenatide, the first GLP-1RA approved in 2005, demonstrated clinical efficacy but its low homology with human GLP-1 and gastrointestinal side effects restricted widespread use (Muttenthaler et al., 2021)
Bill Larkins, President of Injectables for Hikma Pharmaceuticals, said in a statement
Conflict of interest The author has provided advisory services to AstraZeneca, Bayer, Boehringer Ingelheim, Eli Lilly, Merck Sharp & Dohme, and Novo Nordisk, and has received lecture honoraria from Bristol Myers Squibb, Novartis and the above-mentioned companies
Zepbound This table shows the approved titration schedules for both medications
Retas structure allows for consistent receptor binding affinity and reliable results across a range of experimental models
