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Nevertheless, pharmacological levels of OXM (sufficient to activate GLP-1R and GCGR) have shown anti-obesity effects in humans, by significantly reducing appetite (108, 109) and increasing energy expenditure (110)

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it's a no-brainer.' Similarly the clinical study led by Nathan with Habener's team in the late 1980s indicated that diabetic patients given infusions of the GLP-1 (7-37) could not finish their meals

Higher incretin levels increase insulin release and decrease glucagon secretion, lowering blood glucose

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