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Introduction Diabetes, a serious chronic disease, is growing worldwide and is now one of the top ten leading causes of death worldwide ( SCs, as the main glial cells in the peripheral nervous system, possess regenerative properties of interest and have important roles in the nervous system in coordinating the gradual formation of peripheral nerves, ensuring neuronal survival, axonal support and myelination, and promoting neurodegeneration and regeneration ( Programmed cell death (PCD) is an active death process (e.g., apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis) that occurs after a cell receives a certain stimulus or signal in order to maintain the homeostasis of the internal environment ( SCs are an important link in the pathogenesis of DPN: the role of axons SCs encapsulate all axons in peripheral nerves and maintain the long-term functional integrity of axons (26, 27)