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The functional mechanisms linking specific microbial taxa or microbial-derived metabolites to endocrine and metabolic disturbances also remain incompletely understood
Notably, in PCOS patients, increased levels of GABA-producing genera (Bacteroides, Prevotella, and Escherichia) are positively associated with elevated serum LH/FSH ratios (74)
GLP-1 is thought to mediate this through inhibiting Rho GTPase in the cyclic adenosine 3,5-monophosphate (cAMP)/protein kinase A (PKA) pathway [25]
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
Overt biotin deficiency is quite rare but has been documented in patients on prolonged intravenous feeding (parenteral nutrition) without biotin supplementation
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