GLP-1 neurons in the nucleus tractus solitarius widely project to the central nervous system, including the hypothalamus (paraventricular nucleus, supraoptic nucleus, arcuate nucleus, and hypothalamic dorsomedial nucleus), brainstem (parabrachial nucleus, reticular formation, dorsal vagal nucleus), thalamus, and intermedio-lateral cell column
That said, most published studies have used injection methods, and oral bioavailability in humans has not been clinically established
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Avoid dropper contact with skin or mouth to prevent contamination and damage
This is consistent with the fact that examination of the fatty-acid oxidation pathway in fibroblast culture did not reveal any abnormalities to explain the elevations in acyl-carnitines