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The compound then received GRAS (Generally Recognized as Safe) designation from the FDA for use as a food ingredient, which is a separate regulatory category from drug approval

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This method is more effective than oral supplements for people with absorption issues

B12 also plays a role in reducing the risk of osteoporosis, improving brain health, and lowering the risk of heart disease

The optimal concentration can depend on the delivery vehicle and whether penetration enhancers are being used