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We acknowledge that only male mice were used in this study to avoid variability from the female estrous cycle, and therefore sex-specific differences could not be evaluated

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Although previous research suggests that NAC reduces peritoneal TNF- levels 29 , NAC in combination with TNF- did not decrease 12Z cells proliferation

In a phase 2 trial published in The New England Journal of Medicine , retatrutide produced substantial weight loss in adults with obesity or overweight over 48 weeks, with the highest-dose groups achieving reductions that reached up to 24.2%