Both approaches carry similar safety profiles when used appropriately
Okava hopes to carry out similar trials in dogs
In females, L2-Cmu mAb treatment led to a slight, albeit significant reduction in red blood cells (RBCs), hemoglobin (Hb), hematocrit (Hct), white blood cells (WBCs), lymphocytes (Supplementary Table 2), and serum phosphorus (Supplementary Table 3), though most values, with the exception of WBCs, remained within the normal range, and were less severely affected than previously reported with Ganitumab in young CD1 mice 26
The p38 MAPK became more active, while ERK1/2 and JNK1 activity dropped
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