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Native IGF-1 has a frustrating pharmacokinetic limitation: it binds tightly to a family of IGF binding proteins (IGFBPs, particularly IGFBP-3) that sequester it in circulation and keep its free half-life to roughly 15-20 minutes
The likelihood of coverage increases as company size grows, with 40% of companies with more than 500 employees currently covering GLP-1 medications
This usually resolves on its own within a few weeks
Similar to the effect on GBM CSCs observed by Schonberg and colleagues, significant impairment of GBM cell growth upon FTL knockdown was achieved [114]
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