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If maximum weight loss is the goal and you have no contraindications, GLP-1 medications are almost always the first-line recommendation in current obesity medicine guidelines

Establishment of CCl 4 -induced liver fibrosis rat model Male SD rats (180220 g) were subjected to intraperitoneal injection of 40% carbon tetrachloride (CCl 4 )-olive oil solution at 2 ml/kg body weight, twice a week for 28 days

The question often isnt whether they work - its whether theyre accessible