This pairing is especially relevant for Canadians researching peptide stacks aimed at reducing both scale weight and the metabolically dangerous visceral fat that drives cardiovascular risk
If you have dehydration, vomiting, surgery, acute infection, or reduced food intake, ask your clinician whether medication-specific precautions apply
New Evidence That distinction matters
While the medications themselves don't directly cause fluid loss, their effects on appetite, nausea, and digestion can lead to inadequate water intake and electrolyte imbalances that compound dehydration risk
However, recent FDA decisions have removed these medications from the list of substances eligible for compounding, meaning that compounded semaglutide and compounded tirzepatide are no longer generally available