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Preclinical studies suggest GLP-1 agonists may reduce certain inflammatory markers, but these findings have not been validated in rheumatoid arthritis clinical trials
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Further proof of concept for GLP-1 as a chronic treatment for type 2 diabetes came through a study by Zander et al
This model entails that, upon androgen binding, AR is activated, loses interactions with chaperone proteins, translocates to the nucleus where it binds as a dimer to AREs and activates or represses transcription of its target genes with the assistance of a large interactome of regulatory proteins (Fig
