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The reduction in the concentration of GSH in yeasts might have resulted in the consumption of selenium in reactions with free radicals, which are produced in excessive amounts, which was accompanied by an increase in the concentration of the oxidized form of glutathione (GSSG)

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When produced excessively, it may suppress the release of Thyroid Stimulating Hormone from the pituitary. 18 It also forces T4 to be converted to reverse T3 (rT3) which actually blocks thyroid function, even though thyroxine levels look adequate when tested. 19 Blood glucose imbalance also triggers cortisol secretion, and insulin resistance may have a direct negative effect on the thyroid, too