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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management (Ozempic) and chronic weight management (Wegovy)
On the basis of novel data and hypothesis on the possible role of scarce glutathione (GSH) levels in the exacerbation of COVID-19 and of the GSH depleting activity of PAC, this commentary raises the question of whether PAC may be the better choice
In the STEP 3 trial, the company plans to study the combined impact of pharmacotherapeutic intervention with semaglutide and intensive behavioral modification therapy to maximize weight loss in ~600 enrolled patients
However, 1 month of acetylcarnitine supplementation showed only a trend-level improvement in the impact of fatigue on daily life in a placebo-controlled, randomised trial in sixty people with relapsingremitting MS [70]
