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Rotating shift work, which disrupts circadian rhythms, has also been associated with a 4% increased risk for ischemic stroke for every 5 years, with an increased risk of stroke in women with longer durations of shift work ( 15 years) ( Together, the literature supports the notion that a time of day variation in stroke outcome exists, and that patients who experience stroke-like symptoms during the morning, or onset of the active period, have an increased risk for poor outcome

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Manag Care 22:7172 Niessl C, Boulesteix AL, Oh J, Palm K, Schlingmann P, Wygoda S, Haffner D, Wuhl E, Tonshoff B, Buescher A, Billing H, Hoppe B, Zirngibl M, Kettwig M, Moeller K, Acham-Roschitz B, Arbeiter K, Bald M, Benz M, Galiano M, John-Kroegel U, Klaus G, Marx-Berger D, Moser K, Mueller D, Patzer L, Pohl M, Seitz B, Treikauskas U, von Vigier RO, Gahl WA, Hohenfellner K (2022) Relationship between age at initiation of cysteamine treatment, adherence with therapy, and glomerular kidney function in infantile nephropathic cystinosis

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Synapt G2-Si QTOF MS, Waters Corp., Manchester, UK) with reverse-phase (C18) column (Acquity HSS T3