Who Succeeds with Oral Semaglutide: The small number of patients who achieve meaningful weight loss with Rybelsus typically: Follow dosing instructions perfectly every single day Have structured morning routines Combine medication with significant lifestyle changes Have realistic expectations (5-10 pounds, not 30-50 pounds) Use it as a stepping stone before transitioning to injections Bottom Line on Effectiveness: For serious weight loss (15-50+ pounds), injectable GLP-1 medications are dramatically more effective
Hirokawa Y, Nakajima H, Hanemann CO, Kurtz A, Frahm S, Mautner V, et al
Not only do they offer greater dosing flexibility, but they are also more accessible during shortages of brand-name medications
These Authors failed to evidence significant changes in indexes of insulin resistance and speculated that other classical effects of GLP-1 RA, such as suppressed glucagon secretion, with consequent reduced hepatic glucose production, could have been involved in the improvement in glucose metabolism and ectopic fat deposition [54]
Keep it away from children