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A rough rule: if your scale weight is dropping faster than 1 percent of body weight per week over multiple weeks, investigate whether protein intake and training volume are adequate before concluding that faster is better

A 2025 systematic review and meta analysis, which essentially compiles and examines existing studies as a whole to draw broad conclusions, does not regard tirzepatide as superior to semaglutide for chronic weight management

Alharthi WA et al

Additionally, semaglutide reduces overall food intake, which means drinking on an empty stomach becomes more likely, further accelerating alcohol absorption into your bloodstream

Systemic side effects include: Systemic side effects due to using nasal steroid sprays are relatively rare