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No recomendado para menores de edad, mujeres embarazadas o en perodo de lactancia sin supervisin profesional
Nadler adds
One practical consideration: both drugs are best taken in the evening for their respective pharmacodynamic reasons (nocturnal aldosterone surge for spironolactone efficacy, nocturnal hepatic cholesterol synthesis for statin benefit), so single-timepoint dosing is reasonable
Gleaning insight into the mechanisms that underlie neurosteroid involvement in mood pathologies may extend their clinical utility to treatment of mood and anxiety disorders, alcoholism, sleep disorders, chronic pain, traumatic brain injury, neurodegenerative disorders and many others [17]
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Next up: Im even experimenting with much lower doses than what we have in our current program, because I want to see the effects of that. BUT IS IT SAFE LONG-TERM
