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The authors were supported by the Agence Nationale de la Recherche (ANR-2011-BSV1-012-01 MLT2D and ANR-2011-META MELA-BETES), the Fondation de la Recherche Mdicale (Equipe FRM DEQ20130326503), Institut National de la Sant et de la Recherche Mdicale (INSERM) and Centre National de la Recherche Scientifique (CNRS)

Reduced caloric intake combined with metabolic changes can cause fatigue, especially at the maximum dose