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Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects

Vitamin B6 (Pyridoxine) Supports neurotransmitter synthesis, immune function, amino acid metabolism, and digestive enzyme activity

Finding that interesting loop later led to our understanding of the sensing mechanism, Birsoy says

Glucagon-like peptide 1 recruits microvasculature and increases glucose use in muscle via a nitric oxide-dependent mechanism