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doi:10.1164/rccm.201201-0130OC Kukwa W, Migacz E, Druc K, Grzesiuk E, Czarnecka AM
These are normal adaptive responses that occur with any significant weight loss, not specific tolerance to tirzepatide
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Within the brain, DSIP is particularly abundant in the hypothalamus, hippocampus, and limbic regions, where it interacts with multiple peptide and non-peptide mediators, including corticotropin-like intermediate peptide (CLIP), adrenocorticotrophic hormone (ACTH), melanocyte-stimulating hormone (MSH), and melanin-concentrating hormone (MCH)
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