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Genetic evidence, such as GWAS, has identified the single-nucleotide polymorphism (SNP) in GIPR, showing that lower function of GIPR is associated with lower BMI (6466), allowing speculation that higher GIPR activity is obesity promoting

One significant concern is that carnitine does not have an established tolerable upper intake level , meaning there is no official guideline on the maximum safe dose

Specific mechanisms of gut-brain interaction have been identified

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