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Estrogens and experimental ischemic stroke: a systematic review

Digestion Compromised digestion can be an underlying factor, especially of autoimmune thyroid disease such as Hashimotos Thyroiditis, due to the association with increased intestinal permeability (Leaky Gut). 8 This is often mediated by gluten, 9 imbalanced gut bacteria, 10 and stress, 11 which drives autoimmunity, especially if an individual is genetically susceptible. 12 If food is also poorly digested, say from eating on the go, and moves through the gut too fast due to diarrhoea, nutrient absorption becomes harder

Over exposure to oxidative stress, however, can result in the imbalance of the GSH level and lead to cancer, aging, cardiovascular disease, neurodegenerative diseases and other ailments 6,7,8

If not, on what basis are you recommending off-label use