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At initial doses of 1 to 2mg weekly, most researchers report mild appetite suppression within the first week, with effects becoming more pronounced during dose escalation

Metformin (off-label for weight management) Metformin is the most widely prescribed diabetes medication in the world, and while it is not FDA-approved for weight loss, it consistently produces modest weight reduction of 2-5% in clinical studies

Conclusion Nausea is a common but manageable side effect of GLP-1 agonists

Without this, if members start and fail to continue these medications, organizations are then footing the bill without seeing any long-term savings associated with improved health outcomes