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Glutathione inhibits tyrosinase through copper chelation at the active site, pheomelanin pigment shift, and ROS-mediated MITF suppression simultaneously
It is approved only for HIV-associated lipodystrophy
This allows it to reach tissues that wouldnt normally get much ALA which may explain why higher supplemental doses (like 600mg) can affect nerve health, blood sugar, and oxidative stress in ways your bodys natural supply cant.12 Once you take ALA as a supplement, several factors affect how well your body absorbs and uses it
Second, the development of new drugs requires additional and more detailed preclinical and clinical studies to determine whether long-term use is biotoxic, whether the drug has adverse effects on other peripheral organs or whether the drug candidate has a real therapeutic effect on the patients
Endocrine 55(2):376385
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