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While the existing literature on preclinical research shows substantive benefits of antioxidant treatments, clinical studies have reported inconsistent results

Without treatment, this leads to megaloblastic anaemia and potentially serious neurological complications

bioRxiv , 2021.2009.2028.462109 (2021)

The Route of Administration The most significant barrier is that hydroxocobalamin is licensed for parenteral administrationmeaning it must be given by injection (Intramuscular, IM)

Ultraviolet radiation in particular drives photodegradation, a process where light energy breaks chemical bonds and generates reactive oxygen species that attack vulnerable amino acid residues