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A systematic review of the clinical use of Withania somnifera (ashwagandha) to ameliorate cognitive dysfunction

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The observed decrease in esr2a , though nonsignificant, is consistent with reduced esr2 protein levels and with other studies demonstrating an antagonistic effect of BPA on ER 78 due to BPA interfering with the ligand binding domain and preventing the necessary conformation for transcriptional action 7,79