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Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes (FLOW)

PMID:35975308

Complementary modeling studies suggest that GLP-1 RAs such as semaglutide and tirzepatide may disrupt the typical feedback loop in which weight loss leads to compensatory increases in appetite, potentially extending the period of reduction before plateauing occurs

When GLP- 1 receptor agonists are used to treat T2DM, there is also a noticeable reduction in post-meal glycemic fluctuations due to their short-term, transient effect on slowing gastric emptying

Mild to moderate injection site reactions are not a reason to discontinue tirzepatide