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Epidemiological evidence has increasingly suggested that metformin, a commonly prescribed medication for type 2 diabetes, protects against the development of neurodegenerative diseases [23]

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In brain, the properties of GSH transport in isolated rat brain mitochondria seemed to be different from those reported previously for kidney mitochondria, as they were influenced most by inhibitors of the tricarboxylate carrier, citrate, isocitrate, and benzenyl-1,2,3-tricarboxylate (Wadey et al., 2009)