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Taken together, our data indicate that the loss of GSH triggered by Gclc deletion induces a defective mitochondrial accumulation in FoB, which may lead to compensation through upregulation of glycolytic metabolism
NF-kappaB regulation in the immune system
Some healthcare providers may choose to implement a stepwise dose reduction (for example, decreasing from 15 mg to 10 mg to 5 mg over several weeks) not because tapering is pharmacologically required, but to allow time for: Transitioning to alternative therapies Implementing lifestyle modifications Monitoring metabolic parameters Adjusting other medications Psychological preparation for treatment changes This approach represents clinical judgment rather than medical necessity
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