Its worth noting that this is a regulatory review process
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As expected, the three designed sgRNAs efficiently induced indels in Dnd1 in CAG-C9-3 cells (Supplementary information, Fig
Callander N, Markovina S, Eickhoff J, et al
Materials and methods Clinical trial design This was a phase Ib, single centre, open-label study (NCT03350191, ClinicalTrials.gov) with 20 days once daily repeated subcutaneous doses of SAR425899 at 2 different dose regimens (A and B) in overweight to obese T2D patients