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The safety profile of topical GHK-Cu is well-established across decades of use and multiple clinical trials

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However, PSPH ser/gly pathway enzyme genetic aberrations are not acknowledged as important drivers of GBM because of the close proximity of EGFR (chr7:5501901755211628) to PSPH (chr7:5601105156051604), which is a common driver oncogene in GBM [47,48,49]

Sample size calculation The primary outcome was the percentage of body weight loss associated with naltrexone-bupropion over 12 months