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In both the STEP 1 trial and the SURMOUNT-1 trial, participants lost fat mass, but lean mass (muscle mass and anything that is not fat) was lost, too (4, 5)

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The SWI/SNF (BAF) complex, an ATP-dependent chromatin remodeling complex in the nucleus that endows DNA with the capacity for replication and enables selective gene expression and DNA repair and recombination, is frequently mutated in human cancers and thus exerts a great impact on tumorigenesis 51