Key Development Studies The next step in the path of DPP-4 inhibition to approval for clinical use was the development programs for the DPP-4 inhibitors sitagliptin, vildagliptin, saxagliptin, alogliptin, and linagliptin
It was August 2022, exactly when this drug was starting its social-media-fueled ascent as the latest weight loss miracle, one that so many people don't truly need, yet are dying to get their hands on
Patients losing substantial weight should have their dosing reviewed if they approach this threshold, particularly if they also meet one of the other criteria (age 80 years or serum creatinine 133 micromol/L)
This means that users will eat less food per meal and will eat less total food throughout the day
The mechanism parallels the early worsening seen in the DCCT and UKPDS studies after intensive glucose reduction