But the drug hit a supply shortage in late 2021 due to manufacturing issues, which the manufacturer managed to fix in the second half of 2022
However, patients with established type 2 diabetes, significant obesity (BMI 35), cardiovascular risk factors, or previous medication trials should have a provider conversation about whether natural approaches alone meet clinical need
The low rates of clearance (812 mL/h) and long biological half-lives ( ~ 2025 d) of antibodies can lead to prolonged residence times in the body when conjugated with radioisotopes or toxins, potentially causing unexpected pathogenicity and toxicity 5
Gastrointestinal Effects While not always welcome, mild gastrointestinal symptoms such as nausea, decreased appetite, or altered bowel habits can indicate that the medication is engaging its target receptors
Regular Exercise Engaging in regular physical activity strengthens your heart and improves overall cardiovascular health