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Moreover, beyond the loss of exendin-4-induced responses, we also find a significant effect of SPHKAP downregulation in mitochondrial morphology and other parameters under vehicle conditions, suggesting additional effects of this AKAP in -cells

Provide details including: The dose administered The injection site and technique used Any immediate symptoms experienced Keep the pen and packaging to provide batch/lot details to healthcare professionals If you develop severe symptoms such as difficulty breathing, chest pain, severe dizziness, or signs of anaphylaxis, call 999 or attend your nearest A&E department immediately

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Treat cause * Control diabetes * Control hypertension (ACE inhibitors preferred if proteinuria) 2

Adverse events leading to discontinuation were reported by fewer than 6% of participants in both trials