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Additionally, intrastriatal administration of GA and 3OHGA to rats caused increased frequency and duration of seizures, indicating in vivo excitotoxic effects [57, 58]
Unfortunately, no concrete evidence of their efficacy exists to support their beneficial use in addressing the symptoms of mitochondrial diseases [9, 10]
(2007) 22:S3842
This bidirectional NO interaction gives this compound an adaptability in biological environments that single-pathway peptides lack, and may contribute to its consistency of effect across diverse tissue types and experimental conditions
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